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发信人: yangago (yangago), 信区: Immigration
标  题: 分享PL贡献本板
发信站: BBS 未名空间站 (Sun Apr  3 14:06:45 2016, 美东)

USCIS
Attn: I-140
2501 S. State Highway 121 Business
Suite 400
Lewisville, TX 75067

RE: EB-1 Petition for Permanent Residency under the category of Alien of
Extraordinary Ability

Petitioner/Beneficiary: XXX XXX, Ph.D.
Classification Sought: 203(b)(1)(A)
Type of Petition: I-140

Dear Immigration Officer:

This letter is respectfully submitted in support of Dr. XXX XXX’s petition
for classification as a qualified immigrant under the first preference as an
Alien of Extraordinary Ability. Specifically, the evidence submitted will
prove:
I. Dr. XXX is an alien of extraordinary ability on the basis of the
following facts:

A. Dr. XXX qualifies under at least three of the criteria required for this
classification:
1. Dr. XXX has made original scientific contributions of major significance
to her field of endeavor;
2. Dr. XXX has authored scholarly articles in peer-reviewed journals in her
field;
3. Dr. XXX has served as the judge of the work of others;

B. Based on the supporting evidences of the three criteria, Dr. XXX
demonstrates that she is one of a small percentage who are at the very top
of her field, and she has sustained national or international acclaim;

II. Dr. XXX continues to work in her area of extraordinary ability in the
United States; and

III. Dr. XXX’s future stay in the United States will substantially benefit
prospectively the United States.

I. DR. XXX IS AN ALIEN OF EXTRAORDINARY ABILITY

Dr. XXX has been internationally recognized as a scientist with
extraordinary ability in the field of biomedical engineering. (Exhibits 1-51
). As evidence of her significant contributions and research success, Dr.
XXX’s work has resulted in at least 24 peer-reviewed scientific articles
published in top journals. (Exhibits 8-31). Notably, she has been the first
author or corresponding author in a substantial number of her publications.
(Exhibits 8-19). In the scientific community, these designations denote an
author’s key role in his/her publications of original significance. Thus,
Dr. XXX has played a primary role in her influential works. Demonstrating
the high quality of Dr. XXX’s publications, her papers have been published
in prestigious journals in her field and related fields. (Exhibit 33). Her
research has also been presented at major conferences, indicating that her
research is an area of significant interest to the research community. (
Exhibit 32).
Moreover, the major impact of Dr. XXX’s contributions in her field is
clearly evident. Her findings have been cited at least 289 times by
researchers in the field, as evidenced by Google Scholar. (Exhibit 34).
According to the reputable scientific database of Web of Knowledge, compared
to other papers in the Biology & Biochemistry field published in the same
year as each of Dr. XXX’s papers, Dr. XXX’s papers are among the top in
the field. (Exhibit 50). These records are indicative of the definitive
impact of her research on the field.
The dissemination of Dr. XXX’s scientific works has established her as an
influential authority in her field of research. In recognition of her
expertise, Dr. XXX has been directly invited to serve as a peer reviewer by
distinguished journals and a major conference in her field. (Exhibits 35-48)
. A researcher is asked to be a reviewer only if he has the necessary
knowledge, experience, and a high level of expertise in the field. In these
professional capacities, Dr. XXX critiques the works of others for
originality, significance, and technical quality, and thus guides the
direction of future developments in his field. The opportunity to comment on
scientific papers prepared by others is afforded only to the established
experts in one’s field.
Consistent with the evidences discussed above regarding the quality and
impact of Dr. XXX’s work, leading researchers in her field have submitted
letters of support testifying that Dr. XXX is among the elite researchers in
her specialized field. Her recommendations come from scientists at top
research universities throughout the United States and abroad. (Exhibits 1-5
). Please note that included are four (4) Independent Advisory Opinions from
scientists who have not worked with Dr. XXX or do not know Dr. XXX
personally but are familiar with her work and publications. (Exhibits 1-4).
Based on her achievements to date, all these renowned experts have come to
the conclusion that Dr. XXX is a scientist with extraordinary ability in her
field. The following sections will discuss the above evidences in further
detail.

A. DR. XXX’S QUALIFICATIONS AND ELIGIBILITY FOR EB-1A CLASSIFICATION

1. DR. XXX’S ORIGINAL CONTRIBUTIONS OF MAJOR SIGNIFICANCE IN BIOMEDICAL
ENGINEERING

Dr. XXX has earned a reputation as a leading scientist in the field of
biomedical engineering, with an emphasis in biomineralization. Among her
impressive contributions, Dr. XXX has developed valuable techniques that
have greatly elucidated the process of bone and tooth enamel formation. This
formation is known to occur through an early nucleation process involving
the formation and transformation of amorphous calcium phosphate precursors.
For a long time, due to a lack of effective methods, little is known about
the exact crystallization pathways from solvated ions through nuclei or
clusters to the final mineral phase. (See Exhibits 2-4). To this end, Dr.
XXX developed constant composition (CC) crystallization techniques “
uniquely suited for monitoring the earliest nucleation/aggregation stages
for calcium phosphate crystallization under precisely defined conditions.”
(Exhibit 4). Significantly, Dr. XXX’s technique can be “further utilized
to reveal functional relationships between proteins and minerals and provide
mechanistic understanding of bone and teeth biomineralization as well as
pathogenesis of human teeth and development of effective therapeutical
strategies.” (Exhibit 3).
Continuing her research success, Dr. XXX utilized her innovative CC
crystallization technique to clarify a longstanding uncertainty of the
biomineralization process. It is well established that the Amelogenin (Amel)
protein plays a critical role in crystallizing hydroxyapatite (HAP), which
is a natural mineral form of calcium apatite involved in tooth enamel
formation. Prior to Dr. XXX’s research, however, the precise mechanisms by
which Amel is able to nucleate and direct crystal growth through the
regulation of HAP formation remained unclear. Through her investigation, Dr.
XXX revealed that Amel stabilizes calcium phosphate clusters, which
assemble as composite Amel-calcium phosphate nanoclusters. Interestingly,
she further discovered that these clusters co-assemble as chains of
nanoparticles that evolve into long co-aligned crystals that resemble those
found in biological enamel. Thus, Dr. XXX’s study was the “first to
successfully show that bone and teeth closely resemble each other in
composition and in their mechanism of mineral deposition.” (Exhibit 1).
Inspired by these results, independent experts Dr. XXX of the University of
Michigan and Dr. XXX of the University of Washington have cited this work. (
See Exhibits 1-3).
In yet another productive endeavor, Dr. XXX has provided some of the first
direct structural evidence of the docking of amelogenin protein coupled
partners within mineral formation into the multi-functional protein mineral
phases. This information is highly desirable, as knowing the structure of a
protein with the mineral is essential to understanding the protein’s
function. Regrettably, employing traditional methods of determining protein
structure is a time-consuming process. While recent methods have utilized
transmission electron microscopy (TEM) to accelerate analysis time,
integrating proteins with minerals from this type of experiment in situ
remains difficult. Recognizing the need for improvements, Dr. XXX developed
an in vitro method integrating the sequence and techniques of TEM combined
with Scanning Electron Microscopy. Her ingenious method therefore allows for
effective analysis of protein structure. (See Exhibit 3). Dr. XXX’s
innovative method is “central to structural proteomics and facilitating
protein structure-based biomineral development.” (Exhibit 3).
Honing her expertise, Dr. XXX has made significant progress in clarifying
researcher’s understanding of the phosphorylation of a key group of
proteins in bone and tooth development and mineralization, namely the
SIBLINGS protein. As the biological functions of this important group of
proteins are largely dependent on post-translational modification of
phosphorylation, identifying the mechanisms spurring this process is
extremely important. It has recently been discovered that the kinase XXX is
involved in the regulation of biomineralization.  Thus, using a FAM20C
knockout mice model, Dr. XXX systematically analyzed the expression profiles
of SIBLINGs proteins during bone and tooth development. As she observed a
loss of phosphorylation of SIBLINGs proteins due to a lack of FAM20C, her
results revealed that FAM20C is essential to the development and
mineralization of bone, dentin, enamel and cementum. Her mass spectrometry
analyses led to the most comprehensive results about the posttranslational
dynamics of these secretory proteins ever reported in literature. (See
Exhibits 1-2, 4-5). Her groundbreaking work has “helped us better
understand the mechanistic aspects of biomineralization, crucial to the
development of novel treatment modalities for mineralized-tissue diseases
such as osteoporosis and dentinogenesis imperfecta, which affect tens of
millions of Americans.” (Exhibit 1).
Furthermore, Dr. XXX has designed a methodology which is capable of
reconstructing functionally-important mineralization proteins that are
undetectable by mass spectrometry. Before Dr. XXX’s method, the expression
of recombinant proteins required the use of specialized expression vectors
and often necessitated significant restructuring by foreign coding sequences
. Dr. XXX’s method, alternatively, is based on recombinant DNA molecules
formed by laboratory methods using genetic recombination to bring together
genetic material from multiple sources. (See Exhibit 5). She applied this
methodology to investigation of the kinase FAM20C, thereby identifying “
previously-unseen weakly populated intermediate states of these proteins
that are not amenable phosphorylation sites, as determined by mass
spectrometry.” (Exhibit 5).
The above examples are just a few of Dr. XXX’s contributions to biomedical
engineering. For example, Dr. XXX has also conducted a XXX knockout mouse
model, which has led to discoveries that are relevant to human bone
arthritis and cartilage cancer research. (See Exhibit 5). These important
results clearly show that Dr. XXX is one of the preeminent researchers in
her field. Experts in her field draw the same conclusion regarding Dr. XXX
and the value of her research contributions: such innovations and
breakthrough discoveries are achieved only by the very few who have risen to
the top of their field. (Exhibits 1-5). The observations by the experts in
her field are as follows:

“I consider Dr. XXX to be an elite scientist; she has broader knowledge and
scientific expertise than most of the other scientists in her field…Dr.
XXX has deservedly established a respectable reputation and has made herself
a very important niche in the U.S. and international research efforts in
this area through her singular contributions in the field of bioengineering.
..Given her unique background and exceptional contributions that place her
in the upper echelon of bioengineering researchers, she will continue to
contribute important data to the scientific community in her area of
expertise.” (Exhibit 1, XXX, D.D.S., Ph.D.; Professor, Department of XXX,
University of Michigan, USA) (Independent Advisory Opinion)

“Dr. XXX has gained an international reputation for her excellent
achievements and scientific contributions and has distinguished herself as
one of the few who have risen to the very top of the field…Based on Dr. XXX
’s publications, I believe that she possesses an imitable expertise not
only in biomineralization but also in genetic, molecular, and biochemical
examination of genes involved in controlling biomineralization. Her research
has been very productive and is obviously of high quality and demonstrates
immense technical skill. Dr. XXX’s significant and unprecedented
achievements make her an unparalleled candidate to make future contributions
to the field.” (Exhibit 2, XXX, Ph.D.; Affiliate Professor, Materials
Science and XXX; Chief Scientist, Materials Synthesis and Simulation across
Scales, XXX, USA) (Independent Advisory Opinion)

“[Dr. XXX’s] original research results have substantially influenced the
work of others in the same and related fields and place her in a unique
position to lead efforts in this field of endeavor…Dr. XXX has already made
original contributions of a high quality, which enabled her to become an
authoritative figure in the field of biomineralization and biophysics.” (
Exhibit 3, XXX, Ph.D.; Professor, XXX, Germany) (Independent Advisory
Opinion)

“More important in terms of considering her scientific development and
readiness for independent contributions in the future, is that [Dr. XXX has]
demonstrated that she can combine information from a variety of sources to
attack a very complex biological problem.” (Exhibit 4, XXX, Ph.D.;
Professor Emeritus, Department of Cell and XX, Feinberg School of Medicine,
XXX, USA) (Independent Advisory Opinion)

“[Dr. XXX’s] contributions truly establish her as a leading figure with
lasting impacts on an international level. Insights derived from these
studies have a long-term and far-reaching impact to related research efforts
in biomedical sciences. She is a highly skilled and knowledgeable
researcher who represents the best of a new group of researchers working on
the understanding of complex biological phenomena, and I could not be more
supportive of Dr. XXX’s petition for the USA permanent residency.” (
Exhibit 5, XXX, Ph.D.; Professor, Department of Biomedical Sciences, Baylor
College of Dentistry, XXX, USA)

Thus, Dr. XXX’s seminal discoveries within the scientific community,
witnessed by leading experts in her field, amply prove that Dr. XXX has made
multiple original contributions of major significance to this field. These
experts have specifically acknowledged the impact of Dr. XXX’s findings to
the field as a whole. The accomplishments by Dr. XXX are not only novel and
well recognized, but also have had a wide influence in her field.
The letters of endorsement offered above are not the sole evidence
establishing that Dr. XXX’s work has been of major significance to the
field and is held to be extraordinary by the international scientific
community. For instance, Dr. XXX’s achievements have been well-documented
in at least 24 peer-reviewed articles in international, scientific journals.
(Exhibits 8-31). The international attention that Dr. XXX has attracted
with her work includes at least 289 citations from researchers in her field.
(Exhibit 34). One way to place Dr. XXX’s citations into meaningful context
is through the Web of Knowledge Essential Science Indicators “Percentiles
” table. (Exhibit 50). The Web of Knowledge delivers information and
decision support tools for scientists around the world; it is used by over
20 million users. One of the tools available is the Essential Science
Indicators, which determines the influence of certain publications in a
given field of study. With the Essential Science Indicators information, the
most recent Percentiles table displays data on the minimum number of
citations needed to meet certain percentile breakdowns within a scientific
field.
Based on data for the years 2004 to 2014, Dr. XXX’s papers throughout her
research career are ranked among the top compared to other papers in the
field of Biology & Biochemistry, an area closest to her field of expertise.
For example:
• Dr. XXX’s first-authored paper “How amelogenin orchestrates the
organization of hierarchical elongated microstructures of apatite” has been
cited more than 90% of the papers published in the same year in the Biology
& Biochemistry category.

• Dr. XXX’s co-authored paper “Spectroscopic analysis of titanium
surface functional groups under various surface modification and their
behaviors in vitro and in vivo” has been cited more than 90% of the papers
published in the same year in the Biology & Biochemistry category.

• Dr. XXX’s co-authored paper “An amelogenin-chitosan matrix
promotes assembly of an enamel-like layer with a dense interface” has been
cited more than 90% of the papers in the same year in the Biology &
Biochemistry category.

• Dr. XXX’s co-authored paper “Localization and quantitative co-
localization of enamelin with amelogenin” has been cited more than 90% of
the papers in the same year in the Biology & Biochemistry category.

• Dr. XXX’s first-authored paper “Influence of magnesium ions and
amino aids on the nucleation and growth of hydroxyapatite” has been cited
more than 80% of the papers in the same year in the Biology & Biochemistry
category.

• Dr. XXX’s co-authored paper “Nano-crystalline growth of
electrochemically deposited apatite coating on pure titanium” has been
cited more than 80% of the papers published in the same year in the Biology
& Biochemistry category.

(Exhibits 34, 50). In other words, Dr. XXX’s scholarly papers are ranked in
the top 20% or better of the papers in the field of Biology & Biochemistry.
Such attention and citation record would not be possible if her
contributions were not of great value and meaning to the field.
These evidences corroborate the independent experts’ statements that Dr.
XXX has made original contributions of major significance in her field. In
light of such evidences, either taken alone or considered in the aggregate,
Dr. XXX has been a major influence in the field, impacting researchers well
beyond her circle of colleagues.

2. DR. XXX’S AUTHORSHIP OF SCHOLARLY ARTICLES IN PROFESSIONAL & MAJOR TRADE
PUBLICATIONS IN HER FIELD

Dr. XXX has published at least 24 high-quality articles in peer-reviewed
scientific journals in the field of biomedical engineering and related areas
. (Exhibits 8-31). Her series of works have been published in the following
highly respected and widely read publications:
• XXXXXX
• XXXXXX
• XXXXXX
• XXXXXX
• XXXXXX
• XXXXXX
• XXXXXX
• XXXXXX
• XXXXXX
• XXXXXX
• XXXXXX
• XXXXXX
• XXXXXX
• XXXXXX
• XXXXXX


These journals are among the top and most well known in her field. (Exhibit
33). For example, with an impressive impact factor of 6.025, XXXXXX is an “
international journal that publishes peer-reviewed original research reports
, review papers and communications in the broadly defined field of
biomaterials science.” As the “world’s most cited biology journal,” The
FASEB Journal has an impact factor of 5.043 and is ranked #3 out of 54
journals in the Biochemistry, Genetics and Molecular Biology subject area of
the Biotechnology category in the United States based on SJR. With an
impact factor of 4.034, XXXXXX emphasizes “innovative research covering all
aspects of crystal engineering.” Ranking #1 out of 19 journals in the
Materials Science subject area of the Metals and Alloys category in the
United States based on SJR, the Journal of Biomedical Materials Research
Part A has an impact factor of 3.369 and is the official journal of the
Society for Biomaterials (USA), the Japanese Society for Biomaterials, the
Australian Society for Biomaterials, and the Korean Society for Biomaterials
. With an impact factor of 3.302, The Journal of Physical Chemistry B is
ranked #3 out of 21 journals in the Materials Science subject area of the
Surfaces, Coatings and Films category in the United States based on SJR. The
Journal of Structural Biology has an impact factor of 3.231 and publishes
“papers dealing with the structural analysis of living material at every
level of organization;” it is ranked #3 out of 11 journals in the
Biochemistry, Genetics and Molecular Biology subject area of the Structural
Biology category in the United States based on SJR. (Exhibit 33). These are
well-respected, international journals with high standards for publication.
To be published in these leading sources indicates that Dr. XXX’s articles
have met or exceeded the standards imposed by them. 
To be selected for publication in these influential journals attests to the
immense interest in Dr. XXX’s papers. Competition is inherent to science,
as to any activity where talented individuals strive for excellence. It is
not just a matter of limited funding for grants and jobs. There is also an
ever-increasing competition for “mind space” among one's fellow scientists
. With millions of papers per year, scientists do not have time to read
every paper, so some selection is essential. Authors naturally want
visibility for their own work, and publications in these prestigious
journals ensure such visibility. 
Moreover, as discussed above, Dr. XXX’s scholarly publications have been
cited by peer researchers worldwide at least 289 times, demonstrating her
significant impact in her field of expertise. (Exhibit 34). Citations
confirm the impact of a scientist’s contributions. This objective measure
illustrates the high quality of Dr. XXX’s research, the impact of which
reaches well beyond her colleagues and the United States.
These facts evince the vastly superior quality of Dr. XXX’s work and
testify to the widespread influence of her research. Dr. XXX’s credentials
satisfy this criterion based on consistent standards imposed by the
Administrative Appeals Office (AAO). In Exhibit 52 is an AAO decision
overturning a Nebraska Service Center decision, holding that authorship of
23 articles and having made presentations at several conferences with
independent citations was evidence that the petitioner had authored
scholarly articles satisfying this criterion. Compared to the successful
petitioner in the AAO decision with 23 articles, Dr. XXX has published more
with at least 24 articles that have been extensively cited by researchers
around the world.  (Exhibits 8-31).
Overall, Dr. XXX’s publication record is excellent. Clearly, only a
researcher with proven exceptional qualifications and discoveries will be
consistently recognized by these leading publications. In terms of quality,
her publication record exceeds any ordinary level of achievements in the
scientific community.

3. DR. XXX’S SERVICE AS A JUDGE OF THE WORK OF OTHERS

Due to her widespread and lasting influence on the research community in the
field of biomedical engineering, Dr. XXX has been directly invited to serve
as a peer reviewer by numerous well-respected international scientific
journals and a conference. (Exhibits 35-48).
The journals/conference for which Dr. XXX has served as a reviewer include
the following:
• XXX
• The Journal of Physical Chemistry C
• XXX
• XXX
• XXX
• XXX
• XXX
• Journal of Biomedical XXX

• Applied Surface Science
• XXX
• Fibers and Polymers
• Materials Letters
• XXX
• XXX

(Exhibits 35-48). In this capacity, Dr. XXX critiques the work of others for
accuracy, innovativeness, and importance to the field. A reviewer must be
extremely knowledgeable and accomplished in the subject matter area, as he
or she will shape the field by deciding what works get published. Without
demonstrating solid, extraordinary achievements made only by those who have
risen to the top of the field, one cannot be invited to review works of
other researchers, especially in these premier publications at such unusual
frequency.
These are distinguished international journals and a conference in the
various subfields related to Dr. XXX’s research expertise in biomedical
engineering. (Exhibit 49). For instance, with an impact factor of 6.834,
Chemical Communications publishes articles providing information on “new
avenues of research, drawn from all the world’s major areas of chemical
research.” The Journal of Physical Chemistry C has an impact factor of 4.
772, and was cited an astounding 113,624 times in 2014. With an impact
factor of 4.726, the Journal of Materials Chemistry B has a broad scope, and
includes submissions whose novelty and advance is focused on either the
chemistry used to produce the materials or on the properties or applications
of the materials produced. The aim of the International Journal of
Nanomedicine is to “highlight research and development leading to potential
clinical applications in the prevention and treatment of disease;” the
journal has an impact factor of 4.383. XXX XXX  presents innovative research
on all aspects of crystal engineering. RSC Advances has high publication
criteria, requiring that the work be “high quality, well conducted and
advance the development of the field.” (Exhibit 49). Thus, they have high
standards for publication and require peer-reviewers with similarly high
expertise and credentials to judge the scientific originality, techniques,
and merits of submitted manuscripts to ensure conformity to strict
publication standards. Not all journals and conferences are equal, and not
all peer review is equal. Someone who is trusted with the task of protecting
the status quo of leading journals and filtering scientific information for
the readers must be in a position of authority, as Dr. XXX is.
Dr. XXX’s influence in her field is demonstrated by these frequent and
ongoing requests for her professional services for widely read journals and
a conference, which illustrate the high regard for her expertise and her
sustained international acclaim and recognition.

B. THE SIGNIFICANCE OF THE EVIDENCES

In accordance with Kazarian v. USCIS, 596 F.3d 1115 (9th Cir. 2010), the
totality of the circumstances show that Dr. XXX has demonstrated a “level
of expertise indicating that the individual is one of that small percentage
who have risen to the very top of the field of endeavor,” 8 C.F.R. § 204.5
(h)(2); and that Dr. XXX “has sustained national or international acclaim
and that his or his achievements have been recognized in the field of
expertise.” See section 203(b)(1)(A)(i) of the Act, 8 U.S.C. § 1153 (b)(1)
(A)(i), and 8 C.F.R. § 204.5(h)(3).  See also Kazarian, 596 F.3d 1115 at
1119-1120.
Dr. XXX received her Ph.D. degree in Biomedical Engineering from Sichuan
University in China. She has published at least 24 influential articles in
scholarly publications and has presented her research at major international
conferences. Her contributions are cited at least 289 times and are praised
as significant contributions by leading scientists throughout the world,
and thus are widely acclaimed. Further bolstering her credentials, Dr. XXX
has frequently participated in the peer-review process for international
scientific journals and a conference, which would not have been possible but
for Dr. XXX’s outstanding reputation in the field. Thus, Dr. XXX’s
achievements distinguish her as one at the very top of her field.

II. DR. XXX CONTINUES TO WORK IN HER FIELD OF EXTRAORDINARY ABILITY

Dr. XXX is currently a Research Associate at XXX XXX , where she continues
to make further breakthroughs in the biomedical engineering field.  (Exhibit
51). Included is Dr. XXX’s offer of employment letter from XXX XXX of
Pharmacy, which has been signed by Dr. XXX; this document demonstrates Dr.
XXX’s prearranged commitment to continue working in her field of expertise
in the U.S. (Exhibit 51). This field is of great importance, as successful
research in her field enables the development of treatments for a wide
variety of bone related diseases, such as osteoporosis and sclerosis.
Specifically, Dr. XXX has greatly improved researchers’ ability to study
and comprehend the biological mechanisms of hydroxyapatite formation, which
in turn benefits researchers’ understanding of the biomineralization of
bone and tooth growth. Additionally, she has developed methods capable of
determining protein structure in vitro. Having already made numerous first-
in-time contributions employed by many other researchers in the field, Dr.
XXX is certainly well-poised to lead efforts in this field for the benefit
of public health in the U.S.
Independent expert Dr. XXX XXX of the University of Michigan confirms: “[Dr
. XXX] has indeed established a track record of success that provides a
strong assurance of many future benefits to the United States.” (Exhibit 1)
. These evidences combined with Dr. XXX’s record of significant original
achievements in this field, her highly influential publications, and her
extensive professional services for journals and a conference, demonstrate
Dr. XXX’s intent and likelihood to continue pursuing her research career in
the United States. Dr. XXX has shown great commitment to this area and
there is every expectation that she will continue to apply her extraordinary
ability in scientific research to make further significant breakthroughs
and beneficial contributions in this area.

III. SUBSTANTIAL BENEFITS PROSPECTIVELY FOR THE UNITED STATES

Dr. XXX has devoted her work to the field of biomedical engineering, an area
of crucial importance to many U.S. industries, including the medical and
dental industry as well as the pharmaceutical industry. Dr. XXX has
developed numerous techniques and methodologies which have already led to
groundbreaking discoveries. For example, her construction of a constant
composition crystallization system has provided critical insights into the
relationship between functional proteins and biomineral development.
Moreover, her development of a methodology capable of reconstructing
functionally-important enamel proteins has also offered valuable information
into phosphorylation sites. Dr. XXX’s efforts have provided the field with
a better understanding of the biomineralization of bone and enamel
formation; thus, her work has greatly improved scientists’ ability to
development treatment for mineralized-tissue diseases such as osteoporosis
and dentinogenesis imperfecta. As millions of Americans suffer from these
conditions, Dr. XXX’s continued efforts in this field offers innumerable
benefits to the health and welfare of this country.
Affirming the need for Dr. XXX’s sustained presence in the United States,
independent expert Dr. XXX XXX  of the University of Michigan states, “It
would be to our best interest to keep [Dr. XXX] in this country where she
will continue to produce excellent research results that will ultimately
benefit public health. Because we are dependent on research to win the
battle against human genetic diseases, it is vital that we retain skilled
researcher[s] like Dr. XXX in our country.” (Exhibit 1). Consequently, Dr.
XXX’s continued efforts in biomedical engineering are extremely important
to the United States.
With her many innovations and originalities, Dr. XXX has been a pioneer in
the field of biomedical engineering. As noted in the attached exhibits, the
scientific advances generated by her research will benefit the field along
with healthcare in the United States. Therefore, Dr. XXX’s employment and
stay in the United States will prospectively provide substantial benefits
for the United States. (Exhibits 1-5).

IV. CONCLUSION

Dr. XXX is an alien of extraordinary ability who is at the top of the field
of biomedical engineering. As shown in the above sections, considering the
totality of the evidence in context of the final merits of the case, Dr. XXX
is one of the foremost researchers in her field with demonstrated
recognition throughout the world based on her original contributions of
major significance that have been extensively cited, her impressive
publication record in leading journals, and her service as a judge of the
work of others. Overall, Dr. XXX has submitted qualifying evidence for three
of the ten categories and established a level of expertise comparable to
those at the very top of the field with achievements that are commensurate
with sustained national or international acclaim.
Moreover, Dr. XXX continues to work in her field of endeavor in the United
States, and Dr. XXX’s work will prospectively benefit the United States.
Therefore, she qualifies to be classified as an alien of extraordinary
ability as under INA § 203(b)(1)(A). We respectfully request that you
consider this petition and the evidence submitted herewith, and upon
consideration, approve Dr. XXX XXX’s petition for permanent residency as an
alien of extraordinary ability.

Sincerely,



XXX XXX
Attorney at Law

INDEX OF EXHIBITS

Letters of Recommendation

Exhibit 1 Recommendation letter from XXX XXX , D.D.S., Ph.D.; Professor,
Department of Biologic and Material Sciences, University of Michigan, USA (
Independent Advisory Opinion)

Exhibit 2 Recommendation letter from XXX XXX , Ph.D.; Affiliate Professor,
XXX XXX ; Chief Scientist, Materials Synthesis and Simulation across Scales,
Pacific Northwest National Laboratory, USA (Independent Advisory Opinion)

Exhibit 3 Recommendation letter from XXX XXX , Ph.D.; Professor, Department
of Chemistry, XXX XXX , Germany (Independent Advisory Opinion)

Exhibit 4 Recommendation letter from XXX XXX , Ph.D.; Professor Emeritus,
Department of XXX XXX , Feinberg School of Medicine, Northwestern University
, USA (Independent Advisory Opinion)

Exhibit 5 Recommendation letter from Chunlin Qin, Ph.D.; Professor,
Department of Biomedical Sciences, Baylor College of Dentistry, Texas A&M
University, USA

Academic Background

Exhibit 6 Dr. XXX XXX’s Curriculum Vitae
Exhibit 7 Copy of Dr. XXX XXX’s Ph.D. diploma and degree evaluation report
Peer-Reviewed Publications, Presentations & Citation Records

Exhibit 8 Peer-reviewed publication co-authored by Dr. XXX XXX (First Author
) (Corresponding Author)

Exhibit 9 Peer-reviewed publication co-authored by Dr. XXX XXX (First Author
) (Corresponding Author)

Exhibit 10 Peer-reviewed publication co-authored by Dr. XXX XXX (First
Author) (Corresponding Author)

Exhibit 11 Peer-reviewed publication co-authored by Dr. XXX XXX (First
Author)

Exhibit 12 Peer-reviewed publication co-authored by Dr. XXX XXX (First
Author)

Exhibit 13 Peer-reviewed publication co-authored by Dr. XXX XXX (First
Author)

Exhibit 14 Peer-reviewed publication co-authored by Dr. XXX XXX (First
Author)

Exhibit 15 Peer-reviewed publication co-authored by Dr. XXX XXX (First
Author)

Exhibit 16 Peer-reviewed publication co-authored by Dr. XXX XXX (First
Author)

Exhibit 17 Peer-reviewed publication co-authored by Dr. XXX XXX (First
Author)

Exhibit 18 Peer-reviewed publication co-authored by Dr. XXX XXX (First
Author)

Exhibit 19 Peer-reviewed publication co-authored by Dr. XXX XXX (First
Author)

Exhibit 20 Peer-reviewed publication co-authored by Dr. XXX XXX

Exhibit 21 Peer-reviewed publication co-authored by Dr. XXX XXX

Exhibit 22 Peer-reviewed publication co-authored by Dr. XXX XXX

Exhibit 23 Peer-reviewed publication co-authored by Dr. XXX XXX

Exhibit 24 Peer-reviewed publication co-authored by Dr. XXX XXX

Exhibit 25 Peer-reviewed publication co-authored by Dr. XXX XXX

Exhibit 26 Peer-reviewed publication co-authored by Dr. XXX XXX

Exhibit 27 Peer-reviewed publication co-authored by Dr. XXX XXX

Exhibit 28 Peer-reviewed publication co-authored by Dr. XXX XXX

Exhibit 29 Peer-reviewed publication co-authored by Dr. XXX XXX

Exhibit 30 Peer-reviewed publication co-authored by Dr. XXX XXX

Exhibit 31 Peer-reviewed publication co-authored by Dr. XXX XXX (Accepted)

Exhibit 32 Conference presentations/abstracts co-authored by Dr. XXX XXX

Exhibit 33 Information about the journals in which Dr. XXX XXX’s work is
published

Exhibit 34 Google Scholar citation reports of at least XXX XXX  citations to
Dr. XXX XXX’s publications

Judging the Work of Others (Sorted by Journal/Conference)

Exhibit 35 Documentation evidencing Dr. XXX XXX’s reviewer work for
Chemical Communications (10 review)
Exhibit 36 Documentation evidencing Dr. XXX XXX’s reviewer work for XXX XXX
(1 review)

Exhibit 37 Documentation evidencing Dr. XXX XXX’s reviewer work for XXX XXX
  (12 reviews)

Exhibit 38 Documentation evidencing Dr. XXX XXX’s reviewer work for XXX XXX
  (1 review)

Exhibit 39 Documentation evidencing Dr. XXX XXX’s reviewer work for XXX XXX
  (15 reviews)

Exhibit 40 Documentation evidencing Dr. XXX XXX’s reviewer work for XXX XXX
  (6 reviews.

Exhibit 41 Documentation evidencing Dr. XXX XXX’s reviewer work for XXX XXX
  (2 reviews)

Exhibit 42 Documentation evidencing Dr. XXX XXX’s reviewer work for XXX XXX
(1 review)

Exhibit 43 Documentation evidencing Dr. XXX XXX’s reviewer work for XXX XXX
(3 reviews)

Exhibit 44 Documentation evidencing Dr. XXX XXX’s reviewer work for XXX XXX

Exhibit 45 Documentation evidencing Dr. XXX XXX’s reviewer work for  XXX
XXX (1 review)

Exhibit 46 Documentation evidencing Dr. XXX XXX’s reviewer work for XXX XXX
(4 reviews)

Exhibit 47 Documentation evidencing Dr. XXX XXX’s reviewer work for XXX XXX
(13)


Exhibit 48 Documentation evidencing Dr. XXX XXX’s reviewer work for XXX XXX
  (24 reviews)

Exhibit 49 Information about journals/conferences for which Dr. XXX XXX has
served as reviewer

Major Influence of Dr. XXX XXX’s Contributions
Exhibit 50 Web of Knowledge Essential Science Indicator “Percentiles”
table, listing the number of citations corresponding to percentile
breakdowns within specific scientific fields; with background information
about Web of Knowledge

Evidence of Dr. XXX XXX’s Pre-Arranged Commitment to Work in the Field

Exhibit 51 Offer of employment letter from XXX XXX extended to Dr. XXX XXX
Other(s)

Exhibit 52 Copy of AAO decision granting Eb-1A approval to researcher who
has authored 23 articles and has presented work at conferences, along with
“consistent” citations, finding evidence of the alien’s authorship of
scholarly articles in the field in professional or major trade publications
or other media






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